Use Black Seed (Oil) and Raw Honey to Help Prevent and Treat SARS-CoV-2 Related Diseases

January 29, 2024

SARS-CoV-2 is the latest global pandemic declared by the World Health Organization in 2020 and there's no established COVID-19 drug to combat this worldwide health crisis except some recently approved vaccines.

By hitting the global public health sector, this viral infection has created a devastating situation associated with high morbidity and mortality rates along with unprecedented cases of hospitalization in several countries because of its tendency to be highly infective.

These unforeseen challenges forced researchers and pharmaceutical companies to seek potential treatment options and develop cures for this novel strain of coronavirus.

Dedicated healthcare officials are now encouraging people to proactively take preventive measures as the best line of action in fighting coronavirus diseases.

The structural features of the SARS-CoV-2 virus particle occur in related coronaviruses in nature, including the COVID-19 disease and its variants.

Nothing out there seems to be working safely and effectively right now (considering that many people who have received vaccine shots are still getting infected and some, reporting serious side effects. While government departments, health officials, and politicians continue to point fingers at each other, with no shortage of contradicting available information is on the people now to take control.

Contradicting available information on the SARS-CoV-2 coronavirus infections:

America says that fully vaccinated adults do not need a booster shot for now (booster shot is follow up vaccination, sometimes modified to treat new variants).
Canada says fully vaccinated adults may or may not need a booster shot.
Israel says the efficacy of vaccines declines after six months of taking it making it ineffective against future variants, and is not sure about getting the booster shot.
WHO is discouraging people from mixing vaccines.
News reporter asked: if WHO is discouraging people from mixing vaccines why then would health and government authorities advise people that it's ok to mix vaccines?
Health official answered: WHO statement was misinterpreted, they meant that people shouldn't decide for themselves which vaccine to take and not take, and choosing which ones to mix or not- it hasn't been verified which vaccines can be mix together or which not to not.
Some health representatives and medical doctors highly recommend that the population should immediately aim to fortify their immune system (increase antiviral and antioxidants and anti-inflammatory intake) as this is one sure way of fighting SARS-CoV-2 infection effectively and naturally.
People are raising concerns that they may have been mistakenly inoculated with a wrong type of vaccine that's not what they had agreed to.
Some people who have been fully vaccinated, that is, people who have received the first and second dose of vaccination, are still getting infected with coronavirus.
With the recently approved vaccines surrounded by controversies, morbidly and mortality numbers still high, and new variants still popping up in different countries the race to find immediate and definitive cure for coronavirus diseases, with little or no side or after effects, speeds up.
Vaccines have not been fully approved by the FDA.
Health authorities and the media seem to forget to inform the population to optimize their natural immunity, vaccines are designed to mimic the natural immune functions and in some cases suppress the natural immunity, which leads to health complications.

How To Protect Against (or Treat) SARS-CoV-2 Disease, COVID-19

The most important thing to do now in a collective effort to eradicate the coronavirus virus spread is to protect against it. It's imparative to disrupt the virus from infecting the body in the first place. The next this is to prevent the spread by mutation and transmission.

Protecting against the deadly infection means having sufficient immune cells to arrest and disrupt the viral activities at onset, before it causes an infection. Once the infectious attack take place it's more complicated to treat.

Viruses constantly change through mutation, and new variants of a virus are expected to occur. Sometimes new variants emerge and disappear, over certain periods of time.

A typical SARS-CoV-2 virus accumulates only two single-letter mutations per month in its genome — a rate of change about half that of influenza - meaning that if the virus infection multiplies every month, if it's not disrupted at the earliest stage the chances of mutation increases. And when it mutates it creates a more stubborn variant.

According to the World Health Organization (WHO), all viruses – including SARS-CoV-2, the source of coronavirus disease, COVID-19 – evolve over time. When a virus replicates itself, (i.e., multiply or make a copy of itself) it sometimes changes its nature, which is normal for a virus. This replication are called “mutation”, this is what causes new variants to appear.

When a virus is widely spreading in a population and causing many infections, the virus mutation increases, this leads to a more severe health crisis. Therefore, there's an urgency to find effective and safe preventive and treatment solutions.

In order to efficiently overcome the emerging virus variants, the natural immunity is the first line of action!

Concerned medical professionals find it baffling that during this entire one year and half of coronavirus infection health crisis leading medical authorities and the media have been silent on encouraging people to do the most important thing, which is within their control and fundamental - fortifying their immune and metabolic health - increasing antiviral, antioxidant, and anti-inflammatory activities in their body. Also, there're many lifestyle practices that significantly contribute to keeping the immune and metabolic health optimized to ward off or crush these virus infection.

What's The Best Way to Stave Off Coronavirus Diseases?

The health and medical departments officials who do care about the health of the population are proactively seeking alternative effective measures to hasten the eradication of SARS-CoV-2 coronavirus diseases, including novel variants.

They're well-documented effective and safe plant medicines and herbal preparations that medical researchers have provided, there's enough science evidence to support that these options can help prevent and treat SARS-CoV-2 related diseases. The system of plant medicines focuses on treating conditions, disorders, diseases internally, as in internal medicine, as opposed to treatment with synthetic foreign particles. In line with this system of therapeutic treatment, building a strong immune system is the fundamental step.

The immune system is made to fight off foreign invasive pathogens. Pathogens are invasive infectious micro-organisms, germs, or biological agents that cause infectious diseases to their host (cells) in the human body.

The immune system detects harmful pathogenic threats, works quickly to intercept them, kill them off, making it easy to exit the body. The immune system must be equipped to do this. A pathogen is defined as an organism that causes disease to its host, like in the respiratory tract. Pathogens comprise viruses and bacteria as well as unicellular and multicellular eukaryotes.

Eukaryotes are organisms whose cells have a nucleus enclosed within a nuclear envelope, an organism with a complex cell or cells, in which the genetic material is organized into a membrane-bound nucleus or nuclei. These single-celled or multicellular organisms whose cell contains a distinct, membrane-bound nucleus are more harmful to the body and more complicated to treat.

Like the coronavirus, when a virus enters a cell in the body (called a host after infection), it's far from inactive. It becomes active and infective when it sheds its coat, bares its genes and induces the host cell’s own replication machinery to reproduce the invader's DNA or RNA and it goes on to manufacture more viral protein based on the instructions in the viral nucleic acid. The newly created viral bits assemble and more viruses manifest, which also may infect other cells outside the host cell.

These highly dangerous viruses that are enveloped are difficult to navigate and treat. The need to be arrested and destroyed as soon as possible. A well-equipped immune system is the only way to make this possible.

Masking up, washing hands, sanitizing, getting tested and isolating are not practical ways to successfully battle a severe acute respiratory syndrome like the SARS-CoV-2 coronavirus diseases. People are still dying in high numbers.

Remember, the fact that you are able to function normally doesn't mean that you might not be carrying a virus. You have to take adequate care of your health, especially during this perilous time. It's wise to take precautionary measures! Leading a healthier lifestyle and improving the quality of our lives can maximize our immune system to conveniently fight off viral infections and transmission. Read on to learn how to super charge your immune system.

Finding Functional Solutions to Eradicate Coronavirus Diseases

Til date, the coronavirus, COVID-19 has been the most devastating pandemic recorded in human history. Despite the highest medical scientific efforts and investments, a reliable and certified medication has yet to be developed targeting immune system support.

Coronaviruses name came from their shape. They're round viruses surrounded by spiky proteins, this makes them look a bit like a crown or the corona of the sun. In science, the term coronavirus “is less about the genetics and more about the way it appears under a microscope,” explains Brent C. Satterfield. A founder and the chief scientific officer of Co-Diagnostics, company based in Salt Lake City, Utah, and in Gujarat, India.

There're four major types of these viruses that exist - virus is a latin word for "poison", poisonous disease. These viruses are classified by the Greek letters alpha, beta, delta and gamma. Only the alpha and beta types are known to infect human, the delta variant stem from mutation of the lesser variants. These viruses spread through the air or by human fluid droplets called aerosol.

To best deal with this type of virus, it has to be intercepted right from entrance into the body before it latches on to its host cell. This is the exact function of the immune system, but it has to be equipped to do so.

In the distant past, people across the world, in regions like Asia including India, China and Japan, and many African nations have used bioactive plant materials as medicaments since the ancient past. In this modern era, plants are still showing promising therapeutic sources to treat complications like pain, oxidative stress, cancer, diarrhea, depression, fever, and thrombosis, along with infectious diseases.

In perspective, the metabolites alkaloids, flavonoids, polyphenols, tannins, lignins, coumarins, terpenoids, and stilbenes from medicinal plants are widely claimed to be efficacious in ameliorating (making better) infections from pathogenic microorganisms because of their ability to arrest viral protein and enzymatic activities by attaching to them therefore preventing viral penetration into and replication in the host cells. Scientifically, several reports have promoted the possibility of inhibitory actions of plant-derived bioactive compounds against this unprecedented strain of coronavirus, SARS-CoV-2.

Building a solid immune functions consists of many factors, first is nutrition.

Ramping up on quality healthy diets rich in fresh vegetables and fruits, whole foods (avoid processed fatty sugary unhealthy foods), high quality supplements (i.e., vitamins A, ,C, D, and E, also minerals like zinc, calcium, iron, as well as omega-3,6, and 9) is a more natural, practical way to protect against or attenuate the SARS-CoV-2 related illnesses. The immune system has to be equipped to conveniently fight off viral infections and transmission. Nutrition is the number one means of healing the body, preventing and treating most illnesses through maintaining an optimal immune functions.

Your body works hard to keep you alive and well, feeding it body with the right amount of quality nutrients can help it perform better, while ignoring doing so will result to ill-health and poor quality of life. Besides, these raw whole foods are the primary sources of potent phyto- nutrients/chemicals with powerful antiviral, antioxidants, and anti-inflammatory agents that are efficious against foreign pathogenic infectious diseases.

Whilst the immune system is optimized by first feeding the body well, it's necessary to include antiviral bioactive compounds in your healthcare kit with regards to fighting against stubborn and highly infectious disease.

Adding antiviral items to your healthcare regime of the virus eradication will propel the clearance of any existing viral infection activities that might be at the early stages, uncoated or not, within the host cells. Bioactive antiviral foods sources include herbs, spices, plant extracts and compounds.

Antiviral agents are extremely essential when it comes to battling an active virus such as the coronavirus. Available antiviral agents, some are FDA approved, mainly target stages in the viral life cycle. It's imperative to determine the stages of virus infection in order to properly treat it - prevention is the best approach! The most target stages in the viral life cycle are: viral attachment to host cell, uncoating/releasing, synthesis of viral mRNA, translation of mRNA, replication of viral RNA and DNA, maturation of new viral proteins, budding/growing, release of newly synthesized virus, and free virus in body fluids. At least half of the available antiviral agents can be used for the prevention of the progression and the treatment of SARS-CoV-2 and influenza virus-related diseases.

Antiviral agents are widely known and are effective drugs approved by the Food and Drug Administration (FDA) for the prevention and treatment of viral infections. The available antiviral agents mainly target stages in the viral life cycle [1].

While synthetic drugs are gaining attentions, it appears that a number of recent studies and reviews that plant-based substances could also be potential solutions for developing effective and safe remedies against this novel disease are gaining traction.

Citing such recent works, this following review primarily demonstrates the antiviral potency of medicinal plants for inhibiting the coronaviruses in different stages. It also shows the importance of antiviral plants substances, particularly with regards to the development of a broad spectrum medication for coronaviruses including SARS-CoV-2 responsible for COVID-19 [2].

Herbal medicines also have remarkably helped to mitigate the effects of contagious diseases like SARS-CoV species. Many doctors and researchers have started to use herbal medicines in human clinical trials against SARS-CoV-2. Since many botanical drugs already show antiviral efficacy, the use of herbal remedies for therapeutic purposes is a medical gain. Currently, well-known proven herbal medicines with antiviral function are being used as effective supplementary treatments to suppress SARS-CoV-2 outbreaks in infected individuals considering that conventional treatments are still not well flourished in this aspect.

While these plant medicines are highly potent in aiding the treatment and protection against SARS-CV-2 diseases, black seed oil and raw honey combination has been established to provide more superior effect, and safety. However, incorporating some of these medicinal plants into our health regime will ultimately produce a healthier population and economy, sooner.

Black seed is a well-known plant with a vast array of healing and health-promoting abilities and it's been clinically studied and proven to fight against coronavirus infections, such as COVID-19.

Black Seed Efficacy in Preventing and Treating Coronavirus Diseases

What is black seed oil

Nigella sativa (black seed) is a small flowering plant that grows in Africa, Southwest Asia, the Middle East, and Southern Europe.

This shrub plant blue/white flower produces fruit with tiny black seeds with the botanical name Nigella sativa, commonly referred to as "black seed". Black seed has many other names, including black caraway, black cumin, fennel flower, nigella, nutmeg flower, Roman coriander, kalanji and more [3].

Black seed oil is extracted from Nigella sativa seeds the black seed of the plant's flower and is used medicinally due to its many potential therapeutic benefits.

Black seed oil is honored and science expert-backed to possess incredible healing and health-promoting benefits.

With the progress in the area of optimum nutrition, nowadays there is a resurgence of interest in the use of plants as a source of food and medicine. Recently, the usage of phytomedicine has been maximized dramatically, mainly due to its numerous healing powers against a vast array of ailments. Plus, they are, for the most part, easily accessible, low cost, natural, effective, and safe.

With the advancement of modern medicine in human health-care, it is still beyond reach to serve ailing humanity. Therefore, in recent years plant-based sources have been utilized for traditional medicine and clinical phytotherapy.

'Medicinal plants are gifts of nature', black seed is one such plant with a wide range of potential uses, which can be explored as a safe, accessible, and effective herbal medicine for human benefit.

Here're 4 crucial benefits of black seed oil (BSO) in the success of preventing and/or treating coronavirus diseases

Black seed was clinically studied for its efficacy in treating SARS-CoV-2 related diseases with focus on immunomodulatory effects, clearing viral load and activities, expediting survival. It's also medically documented for relieving disspiritedness (low spirit) and fatigue, and repairing pre-existing conditions such as diabetes.

Black seed has been studied for its undeniable effects in the prevention and the treatment of SARS-CoV-2 diseases through 2 main mechanisms, modulating the immune system to wedge against upper respiratory tract (RT) viral infection attack (this causes the severe inflammatory activities in the respiratory tract and subsequent obstruction of respiration that lead to patients gasping for air/oxygen), and facilitating viral shedding to clear out virus infection activities in the RT by healing and repairing it), all of which promote survival chances.

Optimising the immune system to protect against contracting coronavirus is necessary. Clearing viral load and respiratory tract inflammatory damage in the infected is imparative and should be done as soon as possible!

With an increasing environmental changes and pollution, people becoming somewhat relaxed about their ultimate health and wellness, add political interests and conflicts to the mix, infectious diseases are becoming more prevalent and the population must pay attention and protect themselves.

Global sustainability heavily rests on a myriad of benefits provided by the natural ecosystem that support absolute human livelihoods and ultimate well-being. Biodiversity, climate regulation, food security, and water supply should be at heart of government bodies and health authorities, but instead the leaders of nations compromise the sustainable ecosystem and our health and well-being just to line their own pockets. This ecosystem disruption and harvest have lead to some unnatural happenings in the sense of global warming resulting climate disasters, prevalant infectious diseases, and population unproductivity.

No one can be sure enough they won't catch an infection, and unfortunately those we look up to to provide us with quality information to champion a healthy and productive life have seemingly failed. So, protecting yourself and others against these emerging infectious diseases and pressing forward to a revived planet, henceforth, is a must!

As the old saying goes… "Prevention is better than cure"!

There's still hope to eradicate COVID-19; even though the future is uncertain.

Black seed (oil) can aid in arresting and neutralizing viral infection attacks, such as Covid-19, thereby preventing it from infecting your body.

Here're 4 scientific evidence-backed ways black seed (oil) can aid in treating coronavirus SARS-CoV-2 diseases, and the next deadly infectious disease, influenza virus disease

To be clear, coronavirus is a severe acute respiratory syndrome that causes infectious diseases such as Covid-19 disease.

COVID-19, which stands for coronavirus disease of 2019, is an infection caused by a type of coronavirus referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Medical and scientific research are looking at every means possible to prevent and treat coronavirus patients symptoms. Health and medical researchers have studied and reviewed the antiviral efficacy of black seed oil (BSO) on coronavirus, specifically SARS-CoV-2, and the results are impressive.

Black seed works to protect against or treat SARS-COV-2 related diseases. (a) by optimising the immune system and (b), by clearing the viral load of infection and damage in the upper respiratory tract, (c) by stimulating the body's energy storehouse to relieve fatigue and disspiritedness, and (d) by attenuating some underlying health conditions.

Black seed oil efficacy on the immune system

The first thing is to prevent infectious diseases, treating it is more complicated.

In the absence of concrete evidence-based therapy against SARS-CoV-2, some researchers have shifted toward available plant-based therapies, as many drugs are made from plant materials or their derivatives [4].

Despite the development of vaccines recently, extensive multi-site clinical studies are still required to ensure complete and actual efficacy and safe [5].

In the meantime, notable importance is given to exploring potential anti-COVID-19 natural products and herbal medicines as records show that plant-based therapeutics displayed promising efficacy against several viruses by strengthening the immune system, the main focus of successfully protecting or treating SARS-COV-2 or several viral and bacterial diseases is to supercharge your immune system.

There's a report on clinical studies with completed and/or recruiting status that are now exploring the efficacy and safety of traditional medicines (Chinese medicines and Ayurveda), isolated compounds or plant extracts, functional foods, nutraceuticals, mineral and vitamin supplements, herbal preparations, and other plant-based products like those used in, used against SARS-CoV-2. The aim of those studies was to explore, exploit, as well as facilitate the use of such materials as remedial/ treatment and preventive therapies against COVID-19 [6].

The commonly known means by which black seed aids in protecting against infectious diseases like covid-19 is that it increases and activates antibodies in the body to optimally support your immune defence. Hence, having sufficient white blood cells is a key component to having a well functioning immune system, aside from getting enough sleep, managing stress, eating healthier, and getting physical exercise.

A well functioning immune system is crucial and fundamental to fight against infectious diseases. The primary task of the immune system is to fight against and block invasive disease-causing germs (pathogens) like bacteria, viruses, parasites or fungi from infecting your body and to remove them from the body. A well-functioning immune system detects pathogens and responds quickly to eliminate them, thereby preventing them from causing illness and damage to your body. Consequently, not having an optimal immune defense means that the deadly invasive virus can go through to the host cells undetected and cause infectious disease, which, unfortunately, can be fatal. It would be careless for the people not to do anything to curtail this horror. You can start doing someone immediately by using and sharing the scientifically proven solutions outlined here.

Clinically, black seed (oil) has been found to boost the production of white blood cells, thereby increasing the availability of antibodies in the immune system. Antibodies help the immune system to fight infectious organisms and toxins (poisons). Therefore, the black seed or oil increases the production of antibodies, which in turn boosts the immune system and helps it to fight off infectious diseases (e.g. tuberculosis) and pathogens (i.e. viruses) from your body systems.

According to a clinical review, Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone, it was found evident that the black seed and its active agent thymoquinone possessed a useful effect on several human diseases including inflammatory and metabolic syndrome and warranted clinical trials. It was noted that its side effects, if any, were mild [7].

The immune system functions heavily relies on the health of the gut, metabolic health, probiotics is an excellent source of good bacteria that help to rebalance and maintain a harmonious gut ecosystem for stronger immune support, but black seed (oil) helps to treat and restore existing gut conditions and restore it, which in turn supports a well functioning immune system.

A healthy immune system depends on sound gut health, good gut health (ecosystem) is often compromised by common gut disorders/conditions generally known as metabolic syndrome caused by lifestyle and some external factors.

Black seed oil efficacy on viral clearance

Black seed, beyond its safe immune boosting capability, its extraordinary antiviral properties are undeniable - it brings hope in the effort to significantly reverse coronavirus infection disease illness.

The anti-viral properties of black seed stimulates bone marrow and immune cells and enhances interferon production which fights viral infections extensively.

In the effort to find necessary means to combat the coronavirus disease through viral load clearance, Sommer pointed out that the antiviral mechanism of thymoquinone (TQ) is similar to chloroquine and hydroxychloroquine but the antiviral potency and spectrum of black seed's thymoquinone is superior to hydroxychloroquine.

In a study report, Thymoquinone: shield and sword against SARS-CoV-2, since its emergence, the epidemic scale of the new coronavirus (SARS-CoV-2) has escalated. Some governments, medical personnel, and researchers work at the limit of their capabilities to combat the virus threat. Companies are pushing back their projects and directing their focus to help in fighting the virus as well. In this time of global health crisis, every piece of useful information is valuable.

According to the researchers of the stufy, they bring to the attention of the scientific and medical community interest that thymoquinone (TQ), an active plant substance in black seed, holds the promise to significantly contribute in treating people infected with this novel virus by: (1) inhibiting its proliferation, (2) killing it, (3) killing the bacteria associated with pneumonia, (4) its anti-inflammatory and (5) immunomodulatory effect – possibly acting as a prophylactic (safeguard) remedy to prevent SARS-CoV-2 infection at the same time. All these TQ's unique antiviral functions aim to eradicate viral activities and enhance viral clearance.

Due to the volatility of black seed's TQ bioavailability in infected organs, specifically the lungs, nanomedicine is needed and challenged - to facilitate complete assimilation, absorbtion, effectiveness. Nanoscience and nanotechnology deal with nanomedicine, which is applications of nano-drugs and drug delivery systems in the body, and the role they can play in straightening the core body systems and conquering major diseases.

The study's researchers concluded and suggest that nanocarriers targeting the lungs exist and that TQ has already been successfully used in nanomedicines targeting different organs, except the lungs, not yet, but it's possible. The anecdotal (legitimate stories or testimonials told by individuals about a product or experience) was what warranted investigation of the therapeutic effects of TQ and the derivation of a mechanism for its dual antiviral action with regards to COVID-19, by exploiting the material published on the antiviral effect of TQ, they compared the antiviral mechanism of TQ with that of chloroquine (CQ) and hydroxychloroquine (HCQ). Their final analysis indicated that the antiviral action of TQ is similar and even superior to that of CQ and HCQ in treating COVID-19, however, amazingly, without the adverse effects reported for CQ and HCQ. The broad antiviral spectrum and the mechanism by which black seed's most bioactive compound, thymoquinone, presumably destroys the new virus justifies the hypothesis that TQ is effective to treat Covid-19 [8].

The team of researchers added that TQ is a smaller size hydrophobic molecule capable of permeating into and binding to the lipophilic envelope of SARS-CoV-2 and killing the deadly virus by oxidizing it immedately on contact.

In addition, the inhibitory effects of some black seed compounds against SARS-CoV-2 in several molecular binding examples were established in a literature review Nigella sativa L as a potential phytotherapy for coronavirus disease 2019: A mini review of silico studies.

In the review, at least 8 in silico studies have that some compounds of N. sativa (black seed), including nigelledine, a-hederin, hederagenin, thymohydroquinone, and thymoquinone, had moderate to high to affinity with SARS-CoV-2 enzymes and proteins. These compounds may potentially inhibit SARS-CoV-2 replication and attachment to host cell receptors thereby rendering it uninfectious and clearing it from the body.

For example, nigellidine, an alkaloid in black seed, bound to 6LU7 active sites and showed an energy complex score (ie. docking score, free energy binding in relation to binding affinity by equation) close to chloroquine, and better than hydroxychloroquine and favipiravir (an antiviral medication used to treat influenza in Japan and has shown potency against SARS). While a-hederin a saponin in black seed binds to 2GTB active sites and showed an energy complex score better than chloroquine, hydroxychloroquine, and favipiravir with a high therapeutic margin.

Based on this review, the researchers proposed black seed (oil) as a potential pharmacological therapy candidate in the clinical treatment of coronavirus disease such as COVID-19 [9].

According to them, they also found another profound and impressive benefit of BSO, only minor or no adverse side effects were reported.

Moreover, this robust nature's healing and wellness gift is believed to aid in overcoming dispiritedness, which contributes to keeping patients in high spirits, and others in sound uplifted spirit during such perilous times as this. It's recommended to take black seed on a regular basis as it supplies important rich nutritional value, protects human health, and improves overall well-being. High vibration, high frequency energy can go a long way to promote better health during a health crisis.

Black Seed oil efficacy in disspiritedness

The history of black seed, black cumin seed dates back over 3,000 years. It's used in many cultures for preventing and treating many different diseases. In ancient texts and historical documents, black cumin seed is noted for its therapeutic attributes and ability to support the body in its own natural healing processes. Black seed can stimulate the body's energy storehouse.

Archeological studies on BS reported that it's found in several sites from ancient Egypt, including in the tomb of Tutankhamun. It was revered as a beauty secret since ancient times as Queen Nefertiti used it religiously on her skin, which gave her an emulating complexion.

In prophetic medicine, the seeds of Nigella sativa is widely used in the treatment of different diseases and ailments. In Islamic literature, black is considered as one of the greatest forms of healing medicine. It's recommended to be used on a regular basis, according to Tibb-e-Nabwi (Prophetic Medicine). Due to its miraculous power of healing, N. sativa, black seed, has a top place among the top ranked evidence-based herbal medicines [10].

The Persian physician and philosopher Ibn Sina, is commonly known in the Western medical community as Avicenna. He's one of the foremost physicians and Islamic philosophers of his time. His chief medical work, Al-Qanun fi'l-tibb “Canon of Medicine,” which is considered to be the most comprehensive medical encyclopedia ever written by an Arab physician, and was used as the main medical text until the 17th century in Europe. In it, he stated that black seed has preventative and restorative features as it stimulates the body’s energy and helps in recovery from fatigue or dispiritedness [11].

With focus on protecting against and treating coronavirus disease, pre-existing conditions play unwanted roles in exacerbating the virus infection impact and effect on the body. Underlying health conditions such as heart disease, diabetes, overweight or obesity, metabolic syndromes contribute to the severity, hence, detrimental or fatal cases of the SARS diseases.

Black Seed Oil Efficacy in Pre-Existing Condition, Diabetes

In general, keeping your blood sugar regulated is an essential part of living a healthy life.

Unbalanced blood sugar level is a catalyst for chronic diseases like heart disease and it increases the vulnerability to infectious disease impact, especially, with serious infectious diseases of the coronavirus.

Radical or unstable blood sugar levels can increase the risk of heart and kidney disease in the long run but the short term effects of unbalanced blood sugar levels can impact your mental stability, mood balance and energy level leading to increased risk of infectious diseases and death.

Black seed oil may be of great benefit to diabetic patients, according to a review Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review published in Complementary Therapies in Medicine in 2015. Researchers analyzed previously published studies on the efficacy of black seed for the treatment of diabetes and concluded that it can manage blood sugar and cholesterol levels in diabetics [12].

For individuals with diabetes, constant high blood sugar levels have been associated with increased risk of complications in the near future, including kidney disease and eye disease. The health of your kidneys affects all your vital organs. When left unchecked, conditions like anemia and high blood pressure can worsen kidney disease and contribute to heart disease and increased risk of death.

Several studies in individuals with type 2 diabetes indicate that a dose of 2 grams crushed whole black seeds daily may significantly reduce fasting blood sugar levels and hemoglobin A1c (HbA1c) levels, a measure of average blood sugar levels over 2–3 months. The hemoglobin A1c test tells you your average level of blood sugar over the period of past 2 to 3 months [13].

And 1 day's test results don't give you the complete picture of how your treatment is working, it provides more accurate results over a two to three months period.

People who have diabetes need this test regularly to ensure their blood sugar level stays within reasonable range.

The ideal target A1c level for people with diabetes is usually below 7%. The higher the hemoglobin A1c, the higher your risk of having complications related to diabetes. Someone who has had prolonged untreated diabetes might have a level above 8%, which indicates a spike [14].

Another study conducted including 99 adults with type 2 diabetes found that both 1/3 teaspoon (1.5 mL) and 3/5 teaspoon (3 mL) per day of black seed oil for 20 days significantly reduced their HbA1c levels [15].

*Many health complaints can be treated and managed if diagnosed early, before they become life threatening and expensive. Better still, aim to maintain an optimal state of health at all times, this will support you in leading a happy productive life, not a sickly one - now and in the future.

Influenza virus infection is another deadly, yet silent, infectious disease, which can be prevented or treated by using black seed oil regularly.

Black Seed oil on the efficacy on Influenza Virus

Influenza virus is as deadly as coronavirus disease in that it has a very high mortality rate.

The infection we refer to as “the flu” is caused by the influenza virus. Both coronavirus and influenza virus are respiratory illnesses, but they are not the same case.

Both coronavirus and influenza are spread by respiratory droplets on close contact. There are some other similarities between the two, including overlapping symptoms and severity of impact.

Like the COVID-19, influenza (Flu), is a highly contagious and fatal respiratory illness, but they are caused by different viruses. COVID-19 disease is caused by infection from coronavirus (called SARS-CoV-2), and flu is caused by an influenza virus.

Influenza (flu) is a viral infection that attacks your respiratory system — your nose, throat and lungs. Influenza is commonly called the flu that causes cold, it's not the same as stomach "flu" viruses that cause diarrhea.

Influenza infections are transmitted to humans and may cause disease ranging from mild upper respiratory infection (fever and cough) to severe pneumonia, acute respiratory distress syndrome, and even death. Influenza virus is highly deadly and is present in different parts of the world. Many people die from influenza virus every year, especially from common cold influenza that's not detected or treated early.

Here’s a quick look at the number of cases and deaths for the last two flu seasons and COVID-19 to date: 2017-2018 influenza flu number of cases was 45 million, number of deaths was 61, 000, 2018-2019 number of cases was 35 million, number of deaths was 34,157. Coronavirus diseases number of cases worldwide as of July 2021 (starting from December 2019) is 189,699,254, number of deaths is 4,082,59 [16].

A recent study showed that supplementation of black seed or oil would significantly support and enhance immune responsiveness and suppress pathogenicity of influenza viruses in turkeys. Black seed oil inhibited the development and growth of the virus in a dose-dependent manner with different antiviral activities. Significantly higher antiviral titre against avian flu (H9N2 AIV) in turkeys fed a higher dose of black seeds shows the immunomodulatory nature of black seed on the flu virus [17].

While black seed (oil) has been scientifically established to provide support in the treatment of SARS-CoV-2 coronaviruses, combining it with raw honey has been studied and proven to crush SARS-CoV-2 related diseases, such as Covid-19.

BSO combined with honey show affinity for treating coronavirus disease symptoms severity, clear viral load, and expedite survival.

There're overlapping pharmacological profiles of honey and black seed. It's believed that their combination can reduce the severity of disease and control viral replication. Raw honey mixed with black seed has already shown remarkable potential for treating several other diseases. This gives overwhelmed researchers a ray of hope to use this combination in the current pandemic.

Black seed oil + raw honey efficacy on SARS-CoV-2 diseases, including the Covid-19 disease

The SARS-CoV-2 coronaviruses spread through droplets of saliva or discharges from the nose of an infected person cough or sneeze. An angiotensin-converting enzyme has been reported as a cellular receptor to SARS-CoV-2.

SARS-CoV-2, the parent source of coronavirus, was first discovered 53 million years ago during the time of coevolution.

With the advancement in technology, it was learned that the structure of coronavirus is a large pleomorphic sphere-shaped element with protruding spiky outer bubbles. Further, it was learned that the typical coronavirus is about -120nm, the thickness of the envelope is -80nm, and protruding spikes are -2nm long. Within this envelope there's nucleocapsid protein, bound to the positive sense-single-stranded RNA genome.

According to this study, Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanism Action and Future Directions, honey is a well-known potent natural immune booster that improves the proliferations (rapid reproduction) of the T and B lymphocytes and regulates the production of vital pro-inflammatory cytokines from monocytes. In addition, honey contains high medicinal properties which are associated with powerful antioxidants, phenolic compounds [18].

Consuming honey as often as possible might help in reducing the severity of COVID-19 infection symptoms either directly through its effects against SARS-CoV-2 or indirectly through super-charging the immune response [19].

Honey has been a universal natural healer since ancient times in ancient cultures to several ailments including infectious disease attacks.

Till present day, honey is still being used in many natural health and healing products due it's vast therapeutic effects. With the recent infectious disease spread and scientific reports of honey's ability to help curb the coronavirus diseases, researchers decided to further investigate honey and it's healing and health-promoting properties, and they found out an active compound in honey called bacillus subtilis, which produces a notable antiviral agent.

Bacillus subtilis, a compound isolate naturally found in honey that produces a very promising antiviral component known as levan (β-2,6-fructan) that functions against many pathogenic respiratory ribonucleic acid (RNA). Bacillus subtilis antiviral component, levan, delivers the genetic instructions contained in DNA to the rest of the body systems. Messenger RNA (mRNA) targeted vaccines teach body cells how to make a protein that triggers an immune response in the body.

Another proposed mechanism of the strong antiviral activity of honey is through the nitric oxide (No) pathway. Nitric oxide available in honey helps pump oxygen to the respiratory system, the respiratory tract system. Studies have shown that honey raised the concentration of NO at the cellular level significantly. Nitric oxide (NO) pathway is an essential cellular neurotransmitter in several physiological conditions, including viral infections.

Honey's antiviral ability elevated nitric oxide level, and in turn, this neurotransmitter progressively shuts off viral protease enzymes by blocking their capability for viral polyprotein cleavage, consequently, viral RNA synthesis is obstructed at a very early stage. Afterwards, viral replication, the accumulation of viral protein, and the release of the virus from infected cells to the rest of the body are hampered subsequently, destroyed and eliminated from the body systems.

Keeping this in mind, a team of researchers from various institutes across Pakistan, Chile, Canada, and the USA recently collaborated in a clinical trial to investigate the potential effectiveness of honey and Nigella sativa (HNS) in treating COVID-19 patients quickly and efficiently.

Here's a randomized controlled trial study on the action of HNS (honey and Nigella sativa) against SARS-CoV-2 infection, COVID-19

The team of researchers performed a multicenter, randomized, controlled trial in patients with COVID-19 of varying severity, from moderate to severe. Randomized patients received either a combination of 1 mg/kg/day of honey and 80 mg/kg/day of black seed oil or placebo for 13 days. Viral clearance, symptoms alleviation, and 30-day mortality were some of the expected outcomes.

The trial results show that the use of raw honey and black seed oil in COVID-19 patients promotes viral clearance and reduces the severity of the disease!

Out of the 313 patients that were part of the study cohort, 210 patients with moderate symptoms and 103 with severe symptoms of COVID-19 underwent randomization. Among these patients, 107 received honey and black seed oil, and 103 moderate cases received a placebo. Fifty severe COVID-19 patients were given honey and black seed, and 53 severe cases received placebo. Administration of honey and black seed led to alleviation of symptoms by day 3 in moderate cases and day 7 in severe cases [20].

Note, anti-diabetic, anti-hypertensive, cardio-protective and broncho-dilatory properties of the combination of honey and black seed oil make it even more beneficial in diabetic, hypertensive, cardiac and asthmatic patients who have a higher COVID-19 risk and mortality.

These underlying conditions, known and unknown, are the main reason why coronavirus patients experience complications, and in most cases death.

The study's conclusion showed that HNS (honey and Nigella sativa) effectively helped with the symptoms alleviation and viral clearance and reduced mortality in patients with moderate and severe disease. According to the research team, HNS can be used as a safe and effective therapeutic measure in treating COVID-19 patients as it promotes quicker recovery and promotes survival.

Here's a safe black seed oil and raw honey dosage for coronavirus disease, COVID-19

According to the study, Efficacy of honey and Nigella sativa against COVID-19: HNS-COVID-PK Trial, covid-19 treatment, in both moderate and severe cases, honey and black seed oil combination was used as follows: 1 gm/kg/day of honey and 80 mg/kg/day black seed oil or placebo for 13 days. The administration of honey and black seed oil led to alleviation of symptoms by day 3 in moderate cases and day 7 in severe cases. I suggest that you discuss this dosage with a qualified healthcare professional if you are taking prescribed medication.

To proactively protect against coronavirus diseases such as COVID-19, 1-2 teaspoons (upto 10 mL) of black seed oil can be consumed per day, with the combination of a maximum of 1 spoon of honey per day. This is approximately 10 to 12 grams of honey.

If you choose a proprietary black seed oil product with individual packaging and dose, follow the recommended dosage instructions.

For general well-being, 1 to 2 teaspoons of daily intake of black seed oil is usually safe.

There’s limited research on the long-term safety of consuming larger doses of black seed for therapeutic purposes.

Generally, short-term use of 3 months or less hasn’t been linked to any major side effects. However, taking 1 teaspoon (5 mL) of black seed oil per day for 8 weeks did cause minor nausea and bloating in some study participants [21].

Consuming honey as often as possible might help in reducing the severity of COVID-19 infection symptoms either directly through its effects against SARS-CoV-2, or indirectly through super-charging the immune response.

Despite the already established antimicrobial and immune-boosting potency of honey, there's still a lack of evidence and promotion about its potential role amid COVID-19 outbreak. Based on the previously recorded antiviral effects and phytochemical components of honey, a study review explores the evidence for its role as a potentially effective natural product against COVID-19. Although some bioactive compounds present in honey have shown potential antiviral effects (i.e., methylglyoxal, chrysin, caffeic acid, galangin and hesperidinin) or enhancing immune responses (i.e., levan and ascorbic acid), the mechanisms of action for these compounds are still ambiguous. To the best of the knowledge of the team who reviewed the studies, this report summarizes all these bioactive compounds with their probable mechanisms of action as antiviral agents, with specific regard to SARS-CoV-2 [22].

Reduce the amount or frequency and observe the side effects, if it's of concern, consult with a trained physician.

For maintaining general optimal health, follow the above recommendations, use it as wellness medicine. Allow some time before observing results, and monitor effects every 2 months (ie. get a check up on the proposed treatment plan, ensure overall health improvement, and any side or after effect).

How to use to black seed oil and raw honey to protect against (or treat) SARS-CoV-2 virus diseases like COVID-19

Directions for using black seed oil for coronavirus disease is to use the aforementioned dosage above in the following directions.

If you can handle the wild nutty taste, place the right amount in your palm, add the right amount of raw honey, mix together with the other index finger, then slowly lick the mixture up. This works best first thing in the morning when the body is almost and can properly absorb the active ingredients.

Black seed oil has a strong slightly bitter and spicy flavour, often compared to a cumin or oregano taste. As a result, you can consume it with another flavourful ingredient, such as honey, lemon or orange juice - don't forget honey.

Also, BSO may be consumed in its raw form without cooking, one teaspoon at a time, says Stephanie Ferrari, a Massachusetts-based registered dietician.

Avoid heating or cooking it to preserve the nutrients.

The spiritual way to take BSO is by placing the dose amount in the palm of your hand, mix with honey and licking off with your tongue. However, the most common route is to place it under your tongue because the cheek and area under the tongue have many capillaries (tiny blood vessels). Therefore medicines placed there can be quickly and directly absorbed into the bloodstream, and supplied to the entire body. Black seed oil can be ingested in capsule or liquid form as a supplement as well.

The oil can be used topically by massaging it on skin and hair. People can also use the miracle oil by adding it to their shampoo and skin-care products.

*Make Black Seed Oil a staple in your medicine cabinet to nourish your health, and protect you against a wide range of viral infectious diseases.

*Consider speaking with a healthcare professional before you start taking BSO if you are on any other medication, vitamins and supplements or have medical condition(s).

*Supplements aren’t tested for their safety and effectiveness by the Food and Drug Administration (FDA) so it’s important to choose a high quality or a reputable brand.

*As the use of or revisit to natural health products and natural medicines increase the need to understand their interactions grows as well.

Potential side effects and safety concerns of black seed (oil) in treating or preventing SARS-CoV-2 coronavirus, such as COVID-19

One potential concern is that black seed oil may interact with medications that are processed through the cytochrome P450 pathway, a special enzyme pathway that is responsible for processing/metabolising of drugs or supplements.

Cytochrome P450 is a family of isozymes responsible for the biotransformation, metabolism and bioavailability of several drugs. Drug metabolism via the cytochrome P450 system has now emerged as an important determinant in the occurrence of several drug interactions - this can result in drug toxicities, reduced pharmacological effect, and adverse drug reactions. It's important to recognize whether the drugs involved act as enzyme substrates, inducers, or inhibitors in order to prevent clinically significant interactions from occurring.

Avoiding coadministration or eliminating potential situations associated with drugs interaction with CYP450 and adjusting a patient's drug regimen early in the course of therapy can provide optimal response with minimal adverse effects.

Six different P450 isozymes—CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP2E1, and CYP3A4—that play important roles in drug metabolism have been identified recently, and metabolize upto 90% of approved drugs on the market. Of these 6 P450 isozymes, shared metabolism by the CYP3A4 isozyme has resulted in several clinically significant drug-to-drug interactions. More information about the effects of certain drugs on enzyme-mediated biotransformation has led to identification of enzyme inducers and inhibitors, providing even greater insight into the nature of the interactions and how to safely and effectively administer them.

Black seed's thymoquinone affects the CYP2C9 and CYP3A4 enzyme pathways, meaning that these P450 isozymes inhibition or induction expression have to be taken into account in order to avoid diminishing the expected pharmacotherapy result and adverse outcome.

Although a majority of the isozymes are located in the liver, nonhepatic metabolism also occurs in the kidneys, skin, gastrointestinal tract, and lungs. Notable inactivation of some orally administered drugs is due to the first-pass metabolism that takes place in the gastrointestinal tract where the CYP3A4 isozyme is present.

CYP3A4 is a known isozyme that is responsible for metabolism of upto 50 % of available pharmaceutical drugs/agents on the market. To increase plant medicine or drug metabolism and biotransformation in the body, CYP3A4 has to be made abundant to facilitate positive outcomes while decreasing potential risks.

Here's one way we know that you can offset the natural interaction of the black seed oil side effect, due to thymoquinone's inhibitory effect on an enzyme sensitive to superoxide anion generation. Superoxide is an anion radical, it's produced by the one-electron reduction of molecular oxygen. Thymoquinone is well known to inhibit cancerous activities on cells without affecting healthy cells.

In a study, Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme, it concluded that a 14-day course of St John's wort administration significantly induced the activity of CYP 3A4 as measured by changes in alprazolam pharmacokinetics [23].

It's also been reported that after a period of co-administering CYP3A4 inducer, St. John's wort and its substrate medicines, CYP3A4 return to normal, however, there's been positive reports about CYP3A offsetting the short clearance period by holding the induction effect a bit longer. Therefore, using the inducer along with the required drug should be administered carefully [24].

A plant extract, hyperforin, from St John's wort has been found to help make CYP3A4 more available, thereby increasing bioavailability and biotransformation of many drugs, natural or prescribed.

St John's wort (Hypericum perforatum), a flowering shrub native to Europe, contains over two dozens of bioactive constituents, including naphtodiantrons, flavonoids, and phloroglucinols.

The team of researchers tested a number of the isolated component of hypericum extracts, hyperforin, for activity in the PXR transfection assay, notably, the phytochemical was an efficacious activator of PXR (a stable hepatoma cell line expressing the human pregnane X receptor (hPXR) and the cytochrome P4503A4 (CYP3A4)). Full dose–response analysis showed that hyperforin activated PXR with a half-maximal effective concentration (EC50) of 23 nM. Thus, hyperforin from St John's wort is the most potent PXR activator that has been reported to date. The concentrations of hyperforin required to activate PXR are well below the levels that are achieved in humans: Plasma levels of hyperforin peak at ≈380 nM in individuals taking the standard regimen of St. John's wort in its whole form at (3 × 300 mg daily), with steady-state plasma levels estimated to be ≈200 nM. Thus, it is likely that St. John's wort activates PXR in humans [25].

Further studies on cytochrome P450 metabolism will continue to provide clinicians with guidelines for appropriate agents to use when circumstances of drug-drug or drug-nutrient inhibition or induction arise [26].

Things to keep in mind when preventing or treating coronavirus disease

It's now being reported that vaccines should be directed to individuals without covid-19 infection and not to those that might have already contracted it because it can worsen the situation, according to Cleveland Clinic, the second ranked medical clinic in the world.

Medical health officials are now urging people to get on preventive measures as we all work together in an effort to overcome these health crisis.

*Having a well functioning immune system can help you respond better to a vaccine, should you choose to take it.

*Once you contract the dreaded coronavirus related diseases you will have more challenges (fear, stress, cost, time) treating it.

*No one really has your best interest at heart like you do, most of the available vaccines were rushed to produce, and profit seems to be the driving force behind it. The manufacturers of the coronavirus vaccine do not outline or mention their possible contradictions, side or after effects.

*More viral infections and superbugs are emerging. Australia hospitals are currently battling Methicillin-resistant Staphylococcus aureus ( MRSA), a bacterium that causes infections in different parts of the body, which leads to amputation of limbs or deformation of the face. India hospitals, in the wake of the coronavirus disease outbreak crisis, face an unusual viral infection, Mucormycosis, commonly called "black fungus".

*There're also recent disturbing reports of Delta and Delta Pro variants of the coronavirus, we're not sure what could come next.

Here're more steps you can take to safeguard your health to further support you in battling SARS-CoV-2 diseases and other infectious diseases

Indulge in a cleaner, healthier lifestyle to improve the quality of your life. Living a cleaner and healthier life is not just good for you, it's beneficial to other humans, animals, plants, and the environment.

Incorporate these simple quality lifestyle practices to enhance your health quality, and advance life!

Detoxify: Systematically detoxify your body organs and systems, your space, your energy field and chakras (believe it or not they are part of your body and play critical roles in your overall well-being), decalcify your pineal gland (essential for the human growth and development in different aspects). Go for hydrotherapy, lymphatic, head, foot massage regularly.

Nutrition: Increase your nutritional intake and balance. Opt for superfoods and functional foods, nutrients-dense and healing. Take quality multi nutritional supplements if or when you don't get enough whole/fresh daily nutritional requirements. It's better to get your nutrition from whole foods or natural sources than supplements. Eat enough protein, healthy fats (ie. nuts, seeds, fatty fish, eggs, avocado). Include some dark chocolate and a variety of plant-based snacks.

Exercises: Watch your weight. Walk at least 10,000 steps a day, do upper body work out (ie. push-ups on the floor or against the wall, lifting dumbbells or whatever you can use). Do aerobic (water) exercise in a pool, river, or bathtub. These will keep your muscles and joints strong and healthy, regular exercise also keeps you in a happy mood, promotes good sleep, keep sicknesses away.

Nature: Get out and get some sunshine, at least 25 minutes in the morning sun before noon or after 5pm. Take vitamin D supplements if you are not able to get natural sunshine. A vitamin D of 2000-5000 units/day, check if it's good enough. Get outdoors and let nature nurture you! Get to the nearest fresh running water, the negative ions from it will help neutralize the positive ions you from electricity and WiFi magnetic energy. Go into an unpolluted area and plant your beautiful feet on the ground, so that earth's magnetic energy can ground you down to earth.

Sleep: Aim to go to sleep at the same time every night and wake up at the same time everyday, 6-8 hours, as this will help your body to heal and stay healthy. Try to sleep between 9pm and 1 am if you can, use natural sleep aid or foods to help you ease into a good night sleep if you need to. Take hormone balancing agents to rebalance your hormones if or when you don't get to sleep well.

Aromatherapy: Use essential oils diffusers to cleanse your space to relieve stress and lighten up your space. Use crystals to uplift your vibration level, which will promote emotional and mental balance - bring you down to earth.

Adjust habits: Reduce smoking, use of street drugs. Reduce alcohol consumption to minimum. Once you tune in to living a healthier lifestyle you will want less of the unhealthy lifestyle.

Unplug: Make out time to unplug from the noise and bustling of daily life, unplug from electronics, unplug from social and political conflicts - use this time to release and relax.

Get spiritual: Tune into your spiritual life to find meaning and reasons to stay on course. Connect with spiritual practices, rituals, networks, leaders that feel right to you until you find where you truly belong.

Set out days and times to practice these life-changing activities, and they will serve you well in fighting coronavirus and maintaining vital health.

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